| 栗克喜1 雷宁2△ 沈富兵3 朱逸3 郑崛村.硫柳汞SD 大鼠单次静脉注射药代动力学研究[J].,2012,12(3): |
| 硫柳汞SD 大鼠单次静脉注射药代动力学研究 |
| Pharmacokinetics of Thiomersal in SD Rats FollowingIntraveous Administration |
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| DOI： |
| 中文关键词: 426 |
| 英文关键词: 429 |
| 基金项目:国家科技支撑计划课题(2008BAI54B05) |
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| 中文摘要: |
| 目的：研究硫柳汞在SD 大鼠静脉注射后的药代动力学特征。方法：SD 大鼠单剂量（高、低2 个剂量组）静脉注射硫柳汞，以
冷原子吸收测汞法测定不同时间点的血药浓度，用DAS2.0 软件获取各剂量组的主要药代动力学参数。结果：硫柳汞在高（30
mg/kg） 和低剂量（15 mg/kg） 的消除半衰期t1/2z 分别为171.61±0.33h,，156.54±18.61h；AUC0-144h 分别为16748.65±7296.61
mg/L*h，9131.94±1406.68 mg/L*h。结论：硫柳汞在大鼠体内的代谢过程呈线性动力学特征，半衰期约在130～170h 左右。 |
| 英文摘要: |
| Objective: To study the pharmacokinetics of Thiomersal in rats after intravenous injection. Methods: Thiomersal was
intravenously injected to SD rats, once at 15mg/kg and 30mg/kg respectively. Blood samples were serially collected and the mercury
level was determinated by cold-vapour atomic absorption spectroscopy. Pharmacokinetic parameters were integrated using DAS 2.0
software. Results: At the dose of 30 mg/kg and 15 mg/kg, the half-life of Thiomersal were 171.61±0.33h and 156.54±18.61h
respectively, and AUC0-144h were 16748.65±7296.61 mg/L*h and 9131.94±1406.68 mg/L*h, respectively. Conclusion: Thiomersal
presented a linear Pharmacokinetics in the metabolism process of rats with half-life of about 130 ~ 170h or so. |
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