文章摘要
项捷秦鸿雁韩骅.PAQR 膜蛋白家族研究进展[J].,2012,12(1):166-170
PAQR 膜蛋白家族研究进展
Advanced Studies on PAQR Membrane Protein Family
  
DOI:
中文关键词: 孕激素和脂联素分子受体家族  脂联素受体  孕激素膜受体  7 次跨膜蛋白
英文关键词: Progestin and AdipoQ receptors family (PAQRs)  Adiponectin receptors (AdipoRs)  Progesterone membrane receptors (mPRs)  Seven trans-membrane spanning (7TM) sequence
基金项目:国家自然科学基因重点项目(30830067)和国家"973" 计划课题(2009CB521706)资助
作者单位
项捷秦鸿雁韩骅 第四军医大学医学遗传学与发育生物学教研室 
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中文摘要:
      孕激素和脂联素分子受体家族(PAQRs)是一类不同于G 蛋白耦联受体家族的7 次跨膜蛋白家族,目前发现该家族在人类 具有11 个成员。这类蛋白的结构类似于细菌的溶血素蛋白III,跨膜区域完全由一个高度保守的PFAM-UPF0073 结构域构成。对 该家族成员的生理功能研究发现,PAQR1,PAQR2 具有维持代谢稳态和参与炎症反应的作用。PAQR5,PAQR7,PAQR8 对于精子 顶体反应,卵细胞的成熟和细胞凋亡有着重要的调节作用。随着对该家族成员分子的深入研究,一方面将更新对其现有生理病理 过程的认识,另一方面将更加明确该类蛋白介导的信号转导通路,为相关疾病的治疗提供新的靶点和新的策略。
英文摘要:
      Progestin and AdipoQ receptor groups (PAQRs), which lacks significant sequence similarity with any GPCRs but shares similar structure with hemolysin-type III protein, are characterized as a 7 trans-membrane topology wholly encompassed within the PFAM-UPF0073 motif which includes a clear pattern of invariant amino acids during evolution. Now there are 11 members identified in PAQRs, of which PAQR1 and PAQR2 play pivotal roles in the regulation of energy homeostasis and immune response. And PAQR5, PAQR7 and PAQR8 mediate human sperm capacitation and acrosome reaction, maturation of egg cell, and cell apoptosis regulation respectively. Therefore, the study on PAQR family should be helpful to update its knowledge involved in physiological and pathological processes. And exploring the mechanism of RAQRs- mediated signaling pathway will be useful to provide potential therapeutic targets and therapeutic strategies in some relevated diseases.
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