| 罗雁威李昌琪.脑源性神经营养因子前体蛋白生物学效应研究进展[J].,2012,12(1):151-154 |
| 脑源性神经营养因子前体蛋白生物学效应研究进展 |
| Advancement in Research on Biological Effects of ProBDNF |
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| DOI： |
| 中文关键词: 脑源性神经营养因子 脑源性神经营养因子前体蛋白 神经损伤 神经退行性变疾病 |
| 英文关键词: Brain-derived neurotrophic factor Precursor ofbrain-derived neurotrophic factor Nerve injury Neurodegenerative disease |
| 基金项目:国家自然科学基金资助项目（No.30971533） |
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| 中文摘要: |
| 神经营养因子是一类分泌性多肽类生长因子, 可促进中枢和外周神经元的生长、存活以及分化, 但其前体分子却具有不同
的生物学活性, 也有着不同的受体以及细胞内信号通路。本文对近年来关于脑源性神经营养因子前体蛋白的研究予以综述, 着重
讨论其在神经损伤与情绪障碍和神经退行性变疾病模型中的作用。 |
| 英文摘要: |
| The neurotrophins is a class of secreted polypeptide growth factors, which can promote growth, survival and differentiation
of the central and peripheral neurons. But the precursor neurotrophins have different biological activity and different receptors and
intracellular signal pathway. Recent research on the precursor of brain-derived neurotrophic factor (proBDNF) will be reviewed in this
paper. It focus on the role of proBDNF in the mode of nerve injury, emotional disorders and neurodegenerative diseases. |
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