| 李宁李建远.LDH-C：睾丸重要的特异表达基因[J].,2011,11(20):3975-3977 |
| LDH-C：睾丸重要的特异表达基因 |
| LDHC：The most important testis specific gene |
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| DOI： |
| 中文关键词: 精子特异乳酸脱氢酶 LDH-C 睾丸 精子 |
| 英文关键词: Sperm-specific lactate dehydrogenase LDHC Testis Sperm |
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| 中文摘要: |
| 乳酸脱氢酶C（LDHC）是目前已知的最早在男性生精细胞中发现的睾丸特异同功酶。LDHC 最早通过凝胶电泳技术在人精
子及睾丸生精细胞中被发现。免疫组化结果显示LDHC 最早出现在早期的粗线期初级精母细胞中，其数量随着减数分裂逐渐增
加。成熟精子中LDHC 主要定位在精子尾部的主段区域。研究显示，乳酸脱氢酶家族的同功酶在哺乳动物细胞中无所不在，他们
受到发育的调控，具有组织细胞的特异性，且功能多样。本文就LDHC 的发展史及他们在帮助精子完成受精过程中的作用作一综
述。 |
| 英文摘要: |
| Lactate dehydrogenase (LDHC) was the first testis specific isozyme discovered in male germ cells. LDHC was
detected initially in human spermatozoa and spermatogenic cells of the testes by gel electrophoresis. Immunohistochemistry showed that
LDHC was first existed in early pachytene primary spermatocytes with an apparent increase in quantity following meiosis, and it located
in and on the principle piece of the sperm tail. Studies showed that the lactate dehydrogenase isozymes are ubiquitous in vertebrates,
developmentally regulated, tissue and cell specific and multi-functional. Here we review the history of LDHC and the function of LDHC
required for sperm to accomplish their ultimate goal, fertilization. |
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