| 吕锡芳李文婷许跃勋王英红.P-gp、MRP1、GST-π与新疆维吾尔族宫颈癌新辅助化疗疗效的
相关性研究[J].,2011,11(20):3912-3915 |
| P-gp、MRP1、GST-π与新疆维吾尔族宫颈癌新辅助化疗疗效的
相关性研究 |
| Relationship Among the Expression of P-Glycoprotein，Multiple Resistance-Associated Protein-1,and GST-πin Cervical Squmous Cancer forPrediction of Response to Neoadjuvant Chemotherapyin Uigur Women |
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| DOI： |
| 中文关键词: 维吾尔族 新辅助化疗 宫颈癌 P．糖蛋白 多药耐药相关蛋白l 谷胱甘肤．S- 转移酶 |
| 英文关键词: Neoadjuvant Chemotherapy Cervical cancer Multidrug resistance gene 1 P-glycoprotein Multidrug resistance-associated
protein GST-π |
| 基金项目:石河子大学重大攻关专向(500002213403) |
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| 中文摘要: |
| 目的：探讨新疆维吾尔族宫颈癌新辅助化疗前后P-gp、MRPI 和GST-π的表达及其与化疗疗效的关系。方法：运用S-P 法分
别检测维吾尔族妇女宫颈鳞癌组织22 例新辅助化疗前后及正常宫颈组织20 例P-gP、MRPI 和GST-π 的表达水平。结果：①新
疆维吾尔族正常宫颈、初治宫颈癌组织中P-gp 的阳性表达率分别为10%、40.9%；MRP1 的阳性表达率分别为15%、31.8%；
GST-π 的阳性表达率分别为45%、9.01%。P-gp 和GST-π在各组间比较差异均有统计学意义(P<0.05) MRP1 差异无统计学意义
(P>0.05)。②NACT 后宫颈癌组织中P-pg 阳性表达显著上升（P<0.05），有统计学意义。NACT 后宫颈癌组织中MRP1、GST-π 阳性
表达上升但差异无统计学意义（P>0.05）。③新疆维吾尔族妇女新辅助化疗前宫颈鳞癌组织中P-gp、MRP1 及GST-π 表达阴性和
阳性患者NACT 有效率无显著性差异（P>0.05）。结论：P-pg、MRP1、GST-π无法作为化疗敏感性指标预测维吾尔族宫颈鳞癌新辅
助化疗疗效。 |
| 英文摘要: |
| Objective: To investigate the Relationship among the expression of P-glycoprotein，Multiple Resistance-associated
Protein-1,and GST-π in Cervical Squmous Cancer for Prediction of Response to Neoadjuvant Chemotherapy in Uigur woman. Methods:
The specimens of 22 cases with cervical squmous Cancer before and after NACT are examined by S-P immunohistochemistry in ethnic
Uigur women with 20 cases of normal control. Results: ①In ethnic Uigur women:P-gp positive expression rate in normal and cervical
squmous cancer before NACT are 10% and 40.9%；MRP1 positive expression rate in normal and cervical squmous cancer before NACT
are 15%、31.8%；GST-π positive expression rate in normal and cervical squmous cancer before NACT are 45%、9.01%。The positive
expression rate of P-gp and GST-π in cervical squmous cancer before NACT have a significantly higher than in normal cervical (P<0.
05).②In ethnic Uigur women: P-pg positive expression rate after NACT was a significantly higher than that before NACT（P<0.05）. ③In
ethnic Uigur women: P-gp MRP1 and GST-π expression negative rate before NACT had no higher effcctive rate than the positive
groups（P>0.05）. Conclusion: P-glycoprotein,Multiple Resistance-associated Protein-1 and GST-π can not be used as predictive markers
of NACT effective in cervical squmous cancer in Uigur and han women. |
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