张玉晶赵霞霞田执梁姜伟杨艳辉.外源性磷酸肌酸对重度窒息新生儿血清S-100B 蛋白
及NSE 水平的影响[J].,2011,11(20):3894-3896 |
外源性磷酸肌酸对重度窒息新生儿血清S-100B 蛋白
及NSE 水平的影响 |
Effects of Exogenous Phosphocreatine on Level of S-100B Protein and NSEin Serum of Newborn with Serious Asphyxia |
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DOI: |
中文关键词: 磷酸肌酸 缺氧缺血 S-100 NSE NBNA 评分 |
英文关键词: exogenous phosphocreatine hypoxia -ischemic Encephalopathy NSE S100b protein NBNA score |
基金项目:黑龙江省卫生厅课题(2007-324) |
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中文摘要: |
目的:探讨外源性磷酸肌酸对重度窒息新生儿血清S-100B 蛋白和特异性神经元烯醇化酶含量(NSE)的影响。方法:重度窒
息的新生儿40 例,随机分为两组,常规治疗组21 例,给予一般治疗(氧疗、支持、对症)和胞二磷胆碱治疗。磷酸肌酸治疗组19 例,
在常规治疗基础上,生后12h 内给予磷酸肌酸治疗1g/d),另外同期住院的新生儿湿肺和黄疸患儿14 例为正常对照组。均与生后
48h 和生后10 天取血检测血清S-100B 蛋白和NSE 含量。并于生后第14 天进行新生儿行为神经测定(NBNA 评分)。结果:磷酸
肌酸治疗组和常规治疗组患儿生后48h 血清S-100B 蛋白和NSE 含量无显著差异(※P>0.05,※P>0.05),与正常对照组比较差
异具有显著性(△P<0.05,△P<0.05),生后10 天血清S-100B 和NSE 含量在常规治疗组患儿和磷酸肌酸组相比具有显著差异,磷
酸肌酸治疗组两者明显下降(※P<0.05,※P<0.05)。生后三周的行为神经评估(NBNA 评分)<35 分者所占百分比磷酸肌酸治疗
组27%与常规治疗组组53%比较,差异均具有显著性意义(x2=6.112,※P<0.05)。结论:磷酸肌酸用于治疗新生儿缺氧缺血性脑
病能够改善脑的能量代谢,降低脑损伤的程度,改善神经行为,降低致残率。 |
英文摘要: |
Objective: To observe the effect of exogenous phosphocreatine on the level changes of S100b protein and NSE In
serum with serious hypoxia -ischemic encephalopathy in newborn infants. Methods: 40 serious asphxia newborn were randomly devided
into two groups: routin therapy group(21 newborns), routin treatment with oxygen ,nutrition and citicoline(CTL).The treatment group(19
newborns) were given exogenous phosphocreatine(12h after born, 1g/d) besides conventional therapy which was given in control only.the
control group (14 newborn)without asphyxia newborns.The content of S100b protein and NSE in serum were measured using
enzyme-linked immuradsorbent assay (ELISA) after 48h and 10 days.The newborns in both groups were assessed with neurological
function, the NABA scores was recorded. Results: The level of NSE and S100B protein In serum in the treatment group and routin theray
group in 48h were no significantly difference (※P>0.05,※P>0.05).As compared with control group it was significantly difference
(△P<0.05,△P<0.05). The level of NSE and S-100B protein In serum after 10 days between two group were significantly difference, the
treatment group were significantly decreased (※P<0.05,※P<0.05). The NBNA score< 35 point after 3 weeks account for 27.0% in
treatment group and 53% in control group,which had significantly difference (x2=6.112, ※ P<0.05). Conclusions: exogenous
phosphocreatine can protect brain tissure and improve the energetic metabolism of the brain cell , can lessen cerebral ischemic injury,
which can decrease disability rate and improve neurological function. |
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