| 张权宇韩雅玲.阿片肽与P2Y12 受体信号通路的研究进展[J].,2011,11(19):3787-3789 |
| 阿片肽与P2Y12 受体信号通路的研究进展 |
| Opioid peptides and P2Y12 receptor signaling pathway |
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| DOI： |
| 中文关键词: 阿片肽 血小板 P2Y12 糖尿病 氯吡格雷抵抗 |
| 英文关键词: Opioid peptides Platelets P2Y12 Diabetes Clopidogrel resistance |
| 基金项目: |
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| 中文摘要: |
| 糖尿病可增加心血管疾病危险性, 因此糖尿病和心血管疾病的密切关系也日益被人们所重视。糖尿病引发的血小板功能亢
进以及抗血小板药物抵抗的机制尚不明确。阿片肽类物质能够抑制血小板细胞活性以及凝集作用，本文对2 型糖尿病血小板
P2Y12 信号通路高反应性、阿片肽及阿片受体对抗P2Y12 信号通路高反应性的可能机制进行了归纳总结。 |
| 英文摘要: |
| Diabetes increased the risk of cardiovascular disease. Therefore, we must pay more attention on the relationship
between diabetes and cardiovascular. Mechanisms of diabetes induced platelet hyperresponsiveness and the mechanism of antiplatelet
drug resistance were not clear. Meanwhile, platelet activity and aggregation could be inhibited by opioid peptides. The hyper-activity of
P2Y12 receptor and its signaling pathway played an important role in the mechanism of platelet hyperresponsiveness. There were some
key signaling molecules which may have correlation with opioid peptides in the P2Y12 signaling pathways. Our paper summarized on the
mechanism of platelet hyperresponsiveness and opioid peptides decreased platelet hyperresponsiveness in type-2-diabetes. |
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