欢迎访问《现代生物医学进展》编辑部！

目的：探讨内源性促红细胞生成素（EPO）在慢性心力衰竭（CHF）及CHF 贫血发病中的作用及临床价值。方法：采用放射性免疫分析法测定117 例CHF 患者和40 例非CHF 患者血浆EPO 水平，分析EPO 水平与心功能分级、贫血以及CHF 患者预后的关系。结果：心功能II～IV 患者EPO 水平显著上升，与对照组比较均有显著性差异（P<0.05）；EPO 水平随着心功能分级增高而逐渐上升，在各级间比较有显著性差异（P<0.05）；CHF 伴贫血患者EPO 水平随着心功能分级增高和贫血程度的加重而逐渐上升，在各级间比较有显著性差异（P<0.05）；死亡组EPO 水平显著高于存活组，而Hb 水平显著低于存活组，相比较有显著性差异（P<0. 05）。结论：CHF 患者和CHF 伴贫血患者内源性EPO 水平升高，EPO 水平的上升与CHF 患者病情严重程度有关，并且是CHF 患者预后不良的预测指标。

英文摘要:

Objective: To investigate the change of endogenous erythropoietin (EPO) in patients with chronic heart failure (CHF) and its clinical significance. Methods: The plasma EPO level of 117 cases of patients with CHF and 40 cases of patients with non- CHF was measured by radioimmunoassay method. The correlation of EPO level and cardiac function, anemia and prognosis of CHF was analyzed. Results: The EPO level of patients with cardiac function II ~ IV significantly increased, compared with the control group the different was significant (P <0.05); The EPO level of CHF patients increased with the cardiac function gradually increased, the differences was significant in cardiac function II ~ IV (P <0.05); The EPO level of patients with CHF combined anemia increased with the cardiac function gradually increased and the aggravation of serious degree of anemia, the differences was significant (P <0.05); The EPO level of death group was higher than the survival group and the Hb level of death group was lower than the survival group, the difference was significant between the two groups (P <0.05). Conclusion: The endogenous EPO level of patients with CHF and CHF combined anemia increase, the EPO level relates to the severity of CHF, and is a predictor of poor prognosis.

查看全文查看/发表评论下载PDF阅读器

关闭