| 沈佳庆1 杨丽娟1 胡国勇2 程礼1 王兴鹏2.牛磺胆酸钠在大鼠急性胰腺炎模型中的半数致死量(LD50)研究[J].,2011,11(19):3618-3620 |
| 牛磺胆酸钠在大鼠急性胰腺炎模型中的半数致死量(LD50)研究 |
| Median Lethal Dose 50 (LD50) Study of Taurocholic Acid Sodium ina Rat Model of Acute Pancreatitis |
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| DOI： |
| 中文关键词: 牛磺胆酸钠（TC） 急性胰腺炎（AP） 造模 半数致死剂量（LD50） |
| 英文关键词: Taurocholic acid sodium (TC) Acute pancreatitis (AP) Median lethal dose 50 (LD50) |
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| 中文摘要: |
| 目的：通过使用不同浓度的牛磺胆酸钠(TC)建立急性胰腺炎(AP)模型，观察相应的死亡率，进而计算其半数致死量。方法：使
用不同浓度的TC（0 %（wt/vl）、1 %、2 %、3 %、4 %、5 %、9 %）观察AP 造模72 小时后各组的死亡率。同时分析TC 浓度与组织病
理评分、血清淀粉酶和外周血细胞变化的相关性。结果：TC 的半数致死量为3.409 %。并且，TC 的浓度与组织病理评分、血清淀粉
酶和外周血细胞变化密切相关。结论：TC 所致AP 造模的最佳剂量为3.409 %。 |
| 英文摘要: |
| Objective: To investigate the relationship between the doses of TC and the relevant mortality by applying the acute
pancreatitis (AP) model induced by taurocholic acid sodium (TC) . Methods: A series of concentrations of TC (0% (wt/vl), 1%. 2%, 3%,
4%, 5%, 9%) were used and the mortality of animals was detected within 72h after the induction of AP. The correlations between
concentrations of TC and histopathological scores, serum amylase and peripheral blood cells were analyzed. Results: The median lethal
dose (LD50) was 3.409%. There was a close relationship between concentrations of TC and histopathological scores, serum amylase and
peripheral blood cells. Conclusion: The appropriate concentration of TC for the mortality study in this AP model is 3.409%. |
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