| 徐铮1 林嘉盈2△ 凌定文1 刘桂英1.表观遗传学与子宫内膜癌的研究进展[J].,2011,11(18):3592-3594 |
| 表观遗传学与子宫内膜癌的研究进展 |
| Epigenetics and Endometrial Cancer |
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| DOI： |
| 中文关键词: 子宫内膜癌 表观遗传修饰 DNA 甲基化 组蛋白修饰 |
| 英文关键词: Endometrial carcinoma Epigenetics DNA methylation Histone modification |
| 基金项目: |
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| 中文摘要: |
| 长期以来人们一直认为基因突变或缺失参与肿瘤的形成，近年来越来越多证据表明，表观遗传修饰在肿瘤进展中同样具有
非常重要的作用。DNA 甲基化、组蛋白修饰及micro RNA 表达调控等表观遗传机制是子宫内膜癌发生、发展的重要原因之一。表
观遗传学的研究进展不仅有助于子宫内膜癌的早期诊断，对分子靶向治疗子宫内膜癌亦显示出良好的应用前景。 |
| 英文摘要: |
| Although the importance of genetic mutation or deficiency in cancer has long been recognized，the role of epigenetic
modification has been suggested more recently. DNA methylation, histone modifications and deregulation of microRNA expression, are
important in the formation and progression of human endometrial carcinoma. Progress in epigenetics is not only helpful for early diagnosis
of endometrial cancer, molecular targeted therapy for endometrial cancer also shows a good prospect. |
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