| 赵谦杜娟.DPPA2 基因的研究进展[J].,2011,11(18):3565-3568 |
| DPPA2 基因的研究进展 |
| Progress on research of DPPA2 gene |
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| DOI： |
| 中文关键词: DPPA2 胚胎发育 胚胎干细胞 恶性肿瘤 |
| 英文关键词: DPPA2 Embryonic development Embryonic stem cells Malignant tumors |
| 基金项目:国家自然科学基金资助项目(30570937)；中南大学研究生创新基金资助项目(2122-713360010) |
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| 中文摘要: |
| DPPA2 (Developmental pluripotency-associated gene 2)是近年来发现的一种在多能性细胞和某些癌组织中特意表达的基因。
它与早期胚胎发育密切相关，参与维持胚胎干细胞的多能性及自我更新，还在体细胞重编程为多能性诱导干细胞的过程中发挥
了作用。此外，它还是一种新的肿瘤抗原，有望成为某些恶性肿瘤的特异性免疫治疗新靶点。本文就DPPA2 的结构、功能，以及它
与胚胎发育、恶性肿瘤、体细胞重编程的关系等方面的研究进展做一综述。 |
| 英文摘要: |
| Dppa2 (Developmental pluripotency-associated gene 2) has been identified recently as a gene that is specially expressed
in pluripotent cells and some carcinoma tissues. It is closely related to early embryonic development, involving in the maintenance
of pluripotency and self-renewal of embryonic stem cells. In addition, it is a new tumor antigen, promising to be a new target for
the specific immunotherapy of some malignant tumors. In this review，we have discussed the structure and functions of DPPA2，and the
relationships between DPPA2 and embryonic development，malignant tumors，as well as somatic cell reprogramming. |
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