| 韦祝新1 李萍2△ 王仁生1 康敏1 胡凯1.鼻咽癌组织ki67 表达与外周血NK 细胞的关系及意义[J].,2011,11(18):3531-3533 |
| 鼻咽癌组织ki67 表达与外周血NK 细胞的关系及意义 |
| Relationship between Expression of Ki-67 Protein and NK Cellof Peripheral Blood |
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| DOI： |
| 中文关键词: 鼻咽癌 Ki67 基因 NK 细胞 |
| 英文关键词: Nasopharyngeal carcinoma Ki-67 NK cell |
| 基金项目:广西壮族自治区卫生厅医疗卫生科研课题，Z2003052 |
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| 中文摘要: |
| 目的：研究鼻咽癌组织Ki67 的表达及外周血NK 细胞水平的意义。方法：检测66 例鼻咽癌组织Ki67 水平及与外周血NK
细胞的百分含量。结果：Ki67 表达阳性率为96.97%，与临床分期有关(r=0.290,P=0.030<0.05)，与淋巴结转移状态相关性在统计学
上无意义(r=0.068,P=0.412>0.05)；放疗前中后鼻咽癌外周NK 细胞水平差别均有统计学意义(前中、中后、前后F=0.
513,0.627,0.623, P 分别为0.005,0.004,0.000, 均<0.05)；ki67 的表达与放疗后NK 细胞NK 值负相关(r=-0.433,P=0.017<0.05)。结
论：Ki67 的表达可能与临床分期有关，可能与放疗后NK 值有关；Ki67 表达与外周血NK 细胞水平可以提示鼻咽癌组织增殖活
跃程度和机体防御系统的状态。 |
| 英文摘要: |
| Objective: To investigate relationship between expression of Ki-67 protein and NK cell of peripheral blood. Methods:
We detected Ki67 level of NPC tissue and NK cell percentage composition of peripheral blood in 66 NPC cases. Results: The positive
rate of Ki-67 in was 96.97%, The expression intensity of Ki-67 had significant relation with the clinical stage of NPC （r=0.290, P=0.
030<0.05）and no significant relation with metastasis state of lymph (r=0.068,P=0.412>0.05). There are significance differences in the
level of NK cell of peripheral blood either before or underway or after radiotherapy of NPC( the seperated F values of front part, rear part
and middle part are 0.513,0.627,0.623 and the counterparts of P values are 0.005,0.004,0.000, all of which are less than 0.05). The expression
intensity of Ki-67 had Negative correlation with the NK cell of peripheral blood. Conclusion: The expression intensity of Ki-67
may be related with clinical stage and NK level after radiotherapy, expression of Ki-67 protein and NK cell in peripheral blood may indicate
proliferation activity of NPC tissue and status of body defense. |
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