| 李尧徐丹枫△ 崔心刚刘玉杉任吉忠姚亚成高轶.miR-126 调控前列腺癌机制研究[J].,2011,11(17):3393-3396 |
| miR-126 调控前列腺癌机制研究 |
| miR-126 Regulation Mechanism of Prostate Cancer |
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| DOI： |
| 中文关键词: miR-126 前列腺癌 靶蛋白 |
| 英文关键词: miR-126 Prostate cancer Target proteins |
| 基金项目:国家自然科学基金（30973006） |
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| 中文摘要: |
| miR-126 通过靶向作用于表皮生长因子域7(EGFL7)、同源框A9(HOXA9)、胰岛素受体底物-1(IlLS-1)、p85-B 基因等，在转
录后水平调控靶基因表达，在肿瘤形成中起重要作用。前列腺癌细胞中高表达miR-126，能明显下调VEGF-A、EGLF7、HOXA9、
VCAM-l 等与肿瘤生长、转移密切相关的蛋白分子。miR-126 作为抑癌因子，在多种肿瘤中均下调。其抑癌作用及机制在肺癌、白
血病、乳腺癌、宫颈癌等中均已得到证实。本课题拟对miR-126 调控前列腺癌机制做一综述。 |
| 英文摘要: |
| miR-126 has effect on the epidermal growth factor domain 7 (EGFL7), homeobox A9 (HOXA9), insulin receptor
substrate -1 (IlLS-1), p85-B genes by regulation of target levels gene expression. And it plays an important role in tumor formation in the
transcriptional. miR-126, as a tumor suppressor factor, reduced in a variety of tumors. The role and mechanism of tumor suppressor in
lung cancer, leukemia, breast cancer, cervical cancer have been confirmed. There was highly expression of miR-126 in prostate cancer,
and it significantly reduced VEGF-A, EGLF7, HOXA9, VCAM-l, etc. and tumor growth and metastasis of protein molecules. This study
will give a review on miR-126 regulation mechanism of prostate cancer. |
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