| 阿依夏木·伊不拉音艾尼瓦尔·拜克热△ 买买提热厦提·吐尔逊王丽萍.西酞普兰联合利培酮治疗难治性抑郁症的近期临床疗效观察[J].,2011,11(14):2674-2676 |
| 西酞普兰联合利培酮治疗难治性抑郁症的近期临床疗效观察 |
| Citalopram Combined with Risperidone for Refractory Depression |
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| DOI： |
| 中文关键词: 西酞普兰 利培酮 难治性 抑郁症 近期疗效 |
| 英文关键词: Citalopram Risperidone Refractory Depression Recent clinical effect |
| 基金项目: |
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| 中文摘要: |
| 目的：观察西酞普兰联合利培酮治疗难治性抑郁症的近期临床疗效，探讨提高难治性抑郁症近期临床疗效的药物治疗方案
方法：选择难治性抑郁症患者86 例，随机均分为对照组与观察组，对照组给予常规西酞普兰治疗，观察组给予西酞普兰联合利培
酮治疗，比较两组患者治疗第2 周、第4 周、第6 周汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)
评分，比较两组患者治疗第6 周的临床疗效。结果：观察组近期临床疗效好于对照组，HAMD 评分、HAMA 评分和临床疗效比较，
差异具有统计学意义(P＜0.05)；TESS 评分比较，差异无统计学意义(P＞0.05)。结论：药物治疗难治性抑郁症时，应选择西酞普兰联
合利培酮治疗，可提高近期临床疗效，且不加重用药不良反应。 |
| 英文摘要: |
| Objective: To observe the recent clinical effect of citalopram combined risperidone in the treatment of refractory
depression and research the drug treatment programs to improve the recent clinical effect. Method: Collect 86 refractory depression
patients, 43 patients were divided into the control group treated by citalopram, 43 patients were divided into the observation group treated
by citalopram combined risperidone,then compare the HAMD score, HAMA score and TESS score after two weeks', four weeks' and six
weeks' treatment, compare the clinical effect after six weeks' treatment. Result: The observation group's recent clinical effect was better
than the control group's,there was a statistical significant (P＜0.05) in the HAMD score, HAMA score and clinical effect,there was no
statistical significant (P＞0.05) in the TESS score. Conclusion: When we treat refractory depression patients by drug,we should choose
citalopram combined risperidone,it could improve the recent clinical effect and don't increase the adverse drug reaction. |
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