| 李晓晶1 苏燕1△ 闫朝丽2△ 张晶晶1 顾丽1 秦文斌1 李彩萍2 李爱珍2 赵静3.SLC30A8 基因rsl3266634 多态性与内蒙古地区汉族人群2 型糖尿
病的相关性研究[J].,2011,11(12):2221-2223 |
| SLC30A8 基因rsl3266634 多态性与内蒙古地区汉族人群2 型糖尿
病的相关性研究 |
| Association of rs13266634 Polymorphism in SLC30A8 Gene with Type 2Diabetes in Han Population of Inner Mongolia |
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| DOI： |
| 中文关键词: 单核苷酸多态性 SLC30A8 基因 2 型糖尿病 |
| 英文关键词: Single Nucleotide Polymorphism SLC30A8 gene Type 2 Diabetes |
| 基金项目:内蒙古自治区科技计划项目（20090501）、内蒙古自然科学基金面上项目（2009MS1120）
和秦文斌科技助研基金项目（200911）的资助 |
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| 中文摘要: |
| 目的：研究内蒙古地区汉族人群SLC30A8 (solute carrier family 30, member 8) 基因rsl3266634 单核苷酸多态性(Single
nucleotide polymorphism, SNP)的等位基因和基因型频率分布与2 型糖尿病(Type 2 diabetes, T2DM)的相关性。方法：采用等位基因
特异性聚合酶链式反应(AS-PCR)，对222 例内蒙古地区汉族人（其中T2DM 组125 例，正常对照NC 组97 例）rsl3266634 进行基
因分型。结果：T2DM 组中rsl3266634 的C 等位基因频率、CC 基因型频率分别为61.2％和28.4％，均显著高于NC 组的53.1％和
24.7％（P 值均<0.05）；而T2DM 组的TT 基因型频率为6.4％，显著低于NC 组的18.6％(P<0.05)。C 等位基因携带者患T2DM 的
风险是T 等位基因的1.64 倍(OR=1.64, 95％CI=1.125-2.402)。结论：SLC30A8 基因rsl3266634 多态性位点的C 等位基因可能是
T2DM 的风险等位基因，该位点C/T 多态性与内蒙古地区汉族人群T2DM 具有相关性，可能是内蒙古地区汉族人T2DM 的易感基
因之一。 |
| 英文摘要: |
| Objective: To study association of alleles and genotype frequencies of rsl3266634 single nucleotide polymorphism in
SLC30A8 (solute carrier family 30, member 8) gene with type 2 diabetes mellitus in Han population of Inner Mongolia. Methods: Using
allele-specific polymerase chain reaction, the rsl3266634 polymorphism of SLC30A8 gene was genotyped in 222 Han population of Inner
Mongolia, including 125 patients with type 2 diabetes (T2DM group) and 97 normal controls (NC group). Results: In T2DM group, the
frequencies of C allele and CC genotype of rsl3266634 were 61.2% and 28.4% respectively, they were significantly higher than those
(53.1% and 24.7%) in the NC group (P<0.05); The TT genotype was significantly lower than that of the NC group (P<0.05). The risk of
T2DM was significantly increased by C allele with T allelic odd ratio(OR) of 1.64 (OR=1.64, 95% CI=1.125-2.402). Conclusion: C allele
of rsl32666634 polymorphism site in SLC30A8 gene might be a risk factor of T2DM, the site C/T polymorphism is associated with Type
2 diabetes and SLC30A8 gene might be a susceptible gene of T2DM in Han population of Inner Mongolia. |
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