| 王林1 马杰1.干细胞植入缺血大脑后功能研究进展[J].,2011,11(11):2184-2186 |
| 干细胞植入缺血大脑后功能研究进展 |
| Progress in Stem Cell Implantation for Ischemic Brain Diseases |
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| DOI： |
| 中文关键词: 干细胞 缺血性脑疾病 细胞功能 旁分泌效应 |
| 英文关键词: Stem cell Ischemic brain disease Cell function Paracrine pathway |
| 基金项目:国家重点基础发展规划项目（973 项目）（2010CB945203）国家自然科学基金（30770731），
上海优秀学科带头人计划（09XD1403300） |
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| 中文摘要: |
| 目前，干细胞移植在多个中枢神经系统疾病的研究和临床应用中取得突破性进展。其中，干细胞移植治疗脑缺血疾病是细
胞移植治疗研究中最活跃的领域。但是，移植细胞是否具有神经元的功能及细胞移植治疗的机制目前存在很多争议。本文就干细
胞移植治疗缺血性脑疾病后移植细胞的功能和治疗缺血性脑疾病机制的可能途径的研究情况作一综述。 |
| 英文摘要: |
| The ischemic brain disease is one of the most common and severe diseases of the central nervous system. Nowadays,
stem cell therapy, as a novel approach to treat these diseases, attracts great interest in both basic and clinic research. However, the
mechanisms of the implanted stem cells functioning in the host remain to be determined. There are debates on questions like whether the
stem cells display expected activities after transplantation, or whether paracrine pathway plays the major role. This review summarizes
the progress in the recent research on the functions of the implanted stem cells after surgery and the possible mechanisms underlying this
novel therapy. |
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