| 马玉英1 赵文鹏2 豆周林2 王占青2.不同剂量甲泼尼龙对急性百草枯中毒大鼠早期肺损伤干预研究[J].,2011,11(11):2103-2106 |
| 不同剂量甲泼尼龙对急性百草枯中毒大鼠早期肺损伤干预研究 |
| Effects of Different Doses of Methylprednisolone on Early Lung Injuryin Paraquat Toxic Rats |
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| DOI： |
| 中文关键词: 甲泼尼龙 百草枯 急性中毒 肺损伤 |
| 英文关键词: Methylprednisolone Paraquat Intoxication Lung injury |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨不同剂量的甲泼尼龙(Methylprednisolone，MPS)对急性百草枯(paraquat ,PQ)中毒大鼠早期肺损伤的疗效。方法：
采用腹腔注射20%的PQ 溶液制作大鼠急性PQ 中毒的模型，随机均分为五组, 正常对照组(A 组)、染毒组(B 组)、5mg/kg 甲泼尼
龙干预组（C 组）、15mg/kg 甲泼尼龙干预组（D 组）、30mg/kg 甲泼尼龙干预组（E 组）。分三个不同时间点(24、72、168h) 处死大鼠
(每组每时间点6 只)。观察各时间点大体标本，组织病理、肺系数和氧合指数。结果：光镜下肺组织病理学观察，与B 组比较C、D、
E 组大鼠肺的病理学改变,肺泡腔内出血、渗出,炎性细胞浸润、肺泡隔炎性细胞浸润相对较轻，其中以C、E 组减轻最为明显。在各
组相同时间点肺系数：在三个时间点的值均比B 组低（P<0.05），其中E 组在24h、72h 时间点上与C、D 组有显著差异（P<0.05）。
C、D、E 组与B 组的氧合指数的比较各个时间点上均与B 组有差异（P<0.05），三组之间相互无明显差异。结论：本实验结果显示甲
泼尼龙对急性百草枯中毒大鼠的肺损伤具有保护作用，且30mg/kg 甲泼尼龙组要优于5mg/kg、15mg/kg 甲泼尼龙组。 |
| 英文摘要: |
| Objective: To study the effect of different does of Methylprednisolone on early lung injury of rats with paraquat intoxication.
Methods: 114 Wistar rats were randomly divided into 5 groups : normal control group (A group),intoxication group (B group),
5mg/kg Methylprednisolone group (C group)、15mg/kg Methylprednisolone group (D group) and 30mg/kg Methylprednisolone group(E
group). The 22mg/kg paraquat dissolvent was injected by peritoneal injection in B, C, D, E group for once. Then sacrificing the rats in 5
groups at 3 time points (24h ,72h ,168h) , describing lung tissue and observing oxygenation index and lung ratios and the lung pathological
changes by light microscope. Results: C, D,E group compared with B group, the pathological changes of acute lung injury such as
alveolar hemorrhage, exudation, inflammatory cell infiltration, alveolar septal infiltration of inflammatory cells are relatively mild.C and
D Group are the lighter of pathological injury. In each group the same time in lung ratios: B group is the largest, group E in the24h and
72h points score was the lowest (P <0.05). oxygenation index: C,D,E group are increase (P <0.05). Conclusion: 30mg/kg Methylprednisolone
has protective effect on lung injury of rats with paraquat intoxication and it is better than 5mg/kg and 15mg/kg Methylprednisolone. |
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