| 邵扬1 张广耘2△ 袁晓2.核因子-κB 分子生物学特性及其在口腔疾病中的作用[J].,2011,11(9):1789-1793 |
| 核因子-κB 分子生物学特性及其在口腔疾病中的作用 |
| Molecular Biology of Nuclear Factor-κB and Its Role in Oral Diseases |
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| DOI： |
| 中文关键词: 核因子-κB 口腔疾病 |
| 英文关键词: NF-κB Oral diseases |
| 基金项目:国家自然科学基金项目（30770528） |
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| 摘要点击次数: 754 |
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| 中文摘要: |
| 核转录因子-κB(NF-κB)是一种广泛存在于体内多种细胞的核转录因子。静息状态下，NF-κB 二聚体与其抑制蛋白IκB
结合而存在于胞质中。当细胞受到外界刺激时，IκB 磷酸化，使NF-κB 活化进入细胞核，调节相应靶细胞的表达。本文对NF-κB
家族、分子生物学特性及其在口腔疾病中发生和治疗中分子机制进行探讨，为口腔疾病致病机理以及探寻其" 干预治疗" 的关键
靶点提供理论依据和新思路。 |
| 英文摘要: |
| Nuclear factor - κB( NF-κB) is a wide variety of cells in the body of nuclear transcription factor. In the resting
state, NF-κB dimer bound with its inhibitory protein IκB and exists in the cytoplasm. When the cells stimulated by external, IκB can
be phosphorylated, making NF-κB activation and entering the nucleus, then regulating the expression of the corresponding target cells.
This paper on family of NF-κB, Molecular biological characteristics、and to explore its place in the oral diseases and treatment of the
molecular mechanisms, pathogenesis of oral disease, to explore its key targets of therapeutic intervention provide for a theoretical basis
and new ideas. |
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