| 王良1 蔡小攀1 何金2 王国栋1 吴洋1.影响口腔鳞状细胞癌患者预后的临床病理因素分析[J].,2011,11(9):1711-1713 |
| 影响口腔鳞状细胞癌患者预后的临床病理因素分析 |
| Clinical Pathology and Prognostic Factors in Oral SquamousCell Carcinoma |
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| DOI： |
| 中文关键词: 口腔鳞状细胞癌 淋巴结转移 分化 预后 |
| 英文关键词: OSCC Lymph nodal metastasis Differentiation Prognosis |
| 基金项目:上海市科学技术委员会科研计划研究项目（054119630） |
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| 中文摘要: |
| 目的：研究影响口腔鳞状细胞癌（Oral squamous cell carcinoma，OSCC）术后患者预后的临床病理因素。方法：回顾性研究55
例手术治疗的原发口腔鳞状细胞癌患者与预后相关的因素：年龄、性别、发病部位、颈部淋巴结转移情况、肿瘤细胞分化程度等。
结果：平均发病年龄为57.35±12.02 岁，牙龈鳞癌的复发转移率最高（45.5 %），舌部第二（44 %），颊部第三（37.5 %），唇癌预后最
好（0.0 %）。术前颈部淋巴结转移情况、肿瘤细胞分化程度与预后有关。肿瘤细胞的分化程度与术前淋巴结转移无显著相关性。术
前有颈部淋巴结转移合并中低分化与预后差相关。结论：口腔鳞状细胞癌的预后与发病部位无显著相关性。肿瘤中低分化及术前
有淋巴结转移者易出现术后复发转移。 |
| 英文摘要: |
| Objective: The study goal was to determine which clinical features correlated with prognosis in patients surgically
treated for oral squamous cell carcinoma (OSCC). Methods: The records of 55 OSCC patients surgically treated were reviewed retrospectively.
Their prognosis in relation to age, gender, tumor site, neck lymph node involvement, differentiation were analyzed. Results: The
mean age is 57.35±12.02 years. Tumor recurrence or neck nodal metastasis occurred frequently at gingiva (in 45.5 % of cases), followed
by tongue (44%), buccal mucosa (37.5%), and lip (0.0%). The nodal involvement, cell differentiation significantly affected the prognosis
(P <0.05, x2 test). Tumor cell differentiation was no correlated with lymph node metastasis. Combined neck nodal metastasis and poor
differentiation was associated with poor clinical outcome (P<0.05). Conclusions: We conclude that site had little influence on prognosis.
Neck lymph nodal metastasis and poor differentiation are significant prognostic factor of oral squamous cell carcinoma. |
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