| 王洪涛1 张军2 苏菲菲1 于亮1 王彬1 范博渊1 郑强荪1△ 柳荫1.消融右肺动脉神经节丛对肾上腺素能刺激和胆碱
能刺激诱发房颤的影响[J].,2011,11(8):1461-1463 |
| 消融右肺动脉神经节丛对肾上腺素能刺激和胆碱
能刺激诱发房颤的影响 |
| Epicardial Ablation of the Right Pulmonary Artery Ganglionated Plexifor the Prevention of Cholinergic and Beta-adrenergic MediatedAtrial Fibrillation |
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| DOI： |
| 中文关键词: 自主神经 肾上腺素能 胆碱能 神经节丛 阵发性房颤 |
| 英文关键词: Autonomic system Adrenergic Cholinergic Ganglionated plexi Paroxysmal atrial fibrillation |
| 基金项目:军队“十一五”医药卫生科研基金资助项目（01MB126） |
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| 中文摘要: |
| 目的：探讨右肺动脉神经节丛（RPVGP）消融对胆碱能及儿茶酚胺诱发房颤的影响。方法：20 只犬麻醉开胸后，暴露RPVGP，
分别在消融RPVGP 前后，经股静脉静滴乙酰胆碱（ACh） 及儿茶酚胺。测量房颤诱发率及两类递质诱发房颤的阈浓度。结果：
RPVGP 消融前，静滴Ach 和异丙基肾上腺素（IPA）及肾上腺素（EPI）（1～100μmol/l）均可诱发AF，诱发率100％。Ach、IPA 和EPI
的诱发阈浓度分别为2.6±0.3μmol/l，3.3±0.2 μmol/l，5.6±0.2 μmol/l。RPVGP 消融后，Ach 及儿茶酚胺的AF 诱发率分别降至10%及
35%，且三种递质的诱发阈浓度分别提高至2.6±0.3 μmol/l、22.5±2.4μmol/l 和26.±2.6μmol/l（P<0.05）。结论：消融RPVGP 使乙酰
胆碱和儿茶酚胺诱发房颤的阈浓度增高，并降低此二类介质的房颤诱发率。 |
| 英文摘要: |
| Objective: To investigate the effects of right pulmonary artery ganglionated plexi (RPVGP) ablation on cholinergic and
beta-adrenergic mediated atrial fibrillation (AF). Methods: 20 dogs were chosen in this study, and the chest was opened through the left
fourth intercostals, then the RPVGP was exposed. Catecholamines and acetylcholine (ACh) were perfused through the femarol vein to
induce AF. AF inducing rate and the threshold concentration were measured before and after RPVGP ablation respectively. Results: ACh,
isoprenalin (IPA) and adrenaline (EPI) could induce AF before RPVGP ablation, AF inducing rate was 100% . The threshold
concentration of ACh, isoprenalin (IPA) and adrenaline (EPI) was 2.6±0.3μmol/l, 3.3±0.2 μmol/l, 5.6±0.2 μmol/l respectively.
However, after RPVGP ablation, Ach and catecholamines mediated AF inducing rate decreased significantly to 10% and 35% (P<0.05).
And the threshold concentration increased significantly to 2.6±0.3μmol/l, 22.5±2.4 and 26.6±2.6μmol/l respectively (P<0.05).
Conclusions: Catheter ablation of RPVGP increased the threshold concentration of Ach and catecholamines in AF inducing, and
decreased the inducing rate of AF both mediated. |
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