| 肖会敏何悦王四旺△ 王剑波谢艳华袁娟丽何中民.椒目仁油的成分分析及对家兔高血脂模型的影响[J].,2011,11(8):1454-1457 |
| 椒目仁油的成分分析及对家兔高血脂模型的影响 |
| Component Analysis of Semen Oil of Zanthoxylum Bungeanum Maximand Its Effect on Hyperlipidemic Rabbits' Model |
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| DOI： |
| 中文关键词: 气- 质联用仪 椒目仁油 胆固醇 甘油三酯 高密度脂蛋白 |
| 英文关键词: GC-MS Semen oil of the Zanthoxylum bungeanum Maxim CH TG HDL |
| 基金项目:陕西省“13115”科技创新项目（2008ZDKG- 61） |
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| 中文摘要: |
| 目的：分析椒目仁油的成分及探讨其对家兔高血脂模型的影响；方法：①采用GC-MS 分析椒目仁油的成分；②建立家兔高
血脂模型后，以CH、TG、HDL-C 及血液粘度为检测指标，比较椒目仁油的量效与时效关系；结果：①椒目仁油的主要成分是α-
亚麻酸酯与亚油酸等，总相对含量为71.34%；②每个椒目仁油组与模型组及对照组比较均能明显降低CH（P＜0.01）、TG（P＜
0.01）、血液粘度（P＜0.01）以及明显升高HDL-C（P＜0.01），其剂量效果是椒目仁油25mg/kg 组＜50mg/kg 组＜100mg/kg 组，其时
间效果是用药后第2 周＜第4 周＜第6 周；结论：椒目仁油调节血脂的作用主要依赖其中不饱和脂肪酸即α- 亚麻酸与亚油酸，
其调节血脂的效果随着椒目仁油剂量的增加而加强，同时随着使用时间的延长而加强。 |
| 英文摘要: |
| Objective: To analyze the components of Zanthoxylum bungeanum Maxim and to investigate the effect on
hyperlipidemic rabbits'model. Methods: ①Use GC-MS to analyze the components. ② Compare the amount-effect with the time-effect ,
TC,TG,HDL-C and blood viscosity as the detection indexes. Results：①The main components of Zanthoxylum bungeanum Maxim are
α-octadecatrienoic acid and linoleic acid, the amount of which is 71.34%.② CH（P＜0.01）,TG（P＜0.01）, whole blood viscosity（P＜
0.01）significantly decrease and HDL-C increase （P＜0.01）in the model group and blank group compared that of Zanthoxylum
bungeanum Maxim group.And the amount-effect is 25mg/kg group＜50mg/kg group＜100mg/kg group. And the time-effect is after 2
weeks＜after 4 weeks＜after 6 weeks after medication. Conclusion：①The regulating effect of Zanthoxylum bungeanum Maxim on
lipidemia depended on α-octadecatrienoic acid and linoleic acid which was increased with the increasing dosage and time. |
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