| 张延霞1 张桂青1△ 阮宁1 胡敏2 赵倩3.难治性抑郁症治疗前后血浆单胺类神经递质代谢产物的变化[J].,2011,11(7):1352-1354 |
| 难治性抑郁症治疗前后血浆单胺类神经递质代谢产物的变化 |
| Refractory depression: changes of plasma monoamine neurotransmittermetabolite before and after treatment |
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| DOI： |
| 中文关键词: 难治性抑郁症 5-HIAA MHPG |
| 英文关键词: Treatment-Resistant depression 5-HIAA MHPG |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨难治性抑郁症患者抗抑郁剂治疗前后的单胺类神经递质代谢产物的改变。方法：随机入组30 例难治性抑郁症患
者，进行汉密尔顿抑郁量表（HAMD）的临床评定。用酶联免疫吸附方法对这30 例患者进行5-HIAA，MHPG 检测，并与随机选取
的经汉密尔顿抑郁量表（HAMD）临床评定的30 名普通抑郁症患者进行比较。综合治疗8 周后对难治性抑郁症患者进行治疗前
后对比。结果：难治性抑郁症组治疗前血浆5-HIAA，MHPG 浓度低于普通对照组(p<0.05) ，经5- 羟色胺重摄取抑制剂治疗的难治
性抑郁症患者，5-HIAA 和MHPG 含量与治疗前比较均有所升高，差异有显著性（p<0.05）；结论：难治性抑郁症患者存在中枢5-
羟色胺和去甲肾上腺素功能低下；个体化合理使用SSRIs 类药物辅以心理治疗能有效地提高难治性抑郁症患者的外周单胺类递
质水平，减轻患者的抑郁程度。 |
| 英文摘要: |
| Objective: To discuss variety of the metabolite products of monoamine neural transmitter in Treatment-Resistant depression
(TRD) patients before and after therapy. Methods: Thirty TRD patients were recruited and assessed by using HAMD. Plasma
levels of 5-HIAA，MHPG were evaluated and compared using ELISA method in 30 TRD patients and 30 normal depression patients who
were recruited and assessed by using HAMD. After 8 weeks of combined treatment of TRD patients were compared before and after
treatment. Results: The serous levels of 5-HIAA，MHPG before therapy in the TRD group were lower than those in the normal depression
patients group (p<0.05), And the levels were increased after therapy compared with the levers before therapy (p<0.05). After SSRI
treatment, the 5-HIAA and MHPG content were increased compared with that before treatment (p<0.05). Conclusion: TRD patients have
central 5 - HT and norepinephrine dysfunction. Individual rational use of SSRIs drugs combined with psychological treatment can improve
peripheral levels of monoamine neurotransmitters and reduce depression in TRD patients. |
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