| 郭香高立军田霞胡洁张贵英全东琴.非诺贝特固体自乳化制剂（S-SEDDS）体外评价及生物利用度研究[J].,2011,11(7):1266-1269 |
| 非诺贝特固体自乳化制剂（S-SEDDS）体外评价及生物利用度研究 |
| The Solid Self-emulsified Drug Delivery System (S-SEDDS) of Fenofibrate:Evaluation in Vitro and Pharmacokinetic Studies in Vivo |
| |
| DOI： |
| 中文关键词: S-SEDDS 溶出度 粒径 生物利用度 |
| 英文关键词: S-SEDDS Dissolution Particle size Bioavailability |
| 基金项目: |
|
| 摘要点击次数: 928 |
| 全文下载次数: 1936 |
| 中文摘要: |
| 目的：以S-SEDDS 替代液态自乳化制剂中的表面活性剂制备非诺贝特固体自乳化制剂。方法：比较了固体自乳化制剂与市
售产品、液体自乳化制剂的体外溶出情况及体内生物利用度。结果：表明本研究的固体自乳化制剂用水分散后平均粒径为
820.2±26.5（nm）；溶出度试验结果显示，30min 累积溶出度达到80%以上，本研究制备的非诺贝特固体自乳化制剂AUC(0-24)为
22.7±8.2 mgoL-1oh 与SEDDS 的AUC(0-24)（24.9 ±7.6mgoL-1oh）没有显著性差异（P > 0.05），与市售微粉化胶囊（13.8±10.5
mgoL-1oh）相比能够显著提高药物的生物利用度（P<0.05）。结论：S-SEDDS 有液体自乳化给药系统的效果。 |
| 英文摘要: |
| Objective: The solid self-emulsified drug delivery system (S-SEDDS) of fenofibrate was investigated, which contained
solid excipient instead of surfactants usually used in liquid self-emulsified drug delivery system. Methods: Particle size distribution, dissolution
rate in vitro was detected. Rerults: The average size of S-SEDDS after dispersion was 820.2 ± 26.5 (nm). Dissolution test showed
that the accumulated dissolution of S-SEDDS was about 80% within 30min. In vivo study, AUC (0-24) was 22.7 ±8.2 mgoL-1oh in
S-SEDDS and 24.9 ± 7.6 mgoL-1oh in SEDDS. There was no significant difference between S-SEDDS and SEDDS, while they were all
better than that of the market capsule (13.8±10.5 mgoL-1oh). Conclusions: S-SEDDS could enhance the dissolution rate and the bioavailability
of fenofibrate free of surfactant. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
