| 张志峰1,2 刘绍明2△ 修斌华2.血红素氧合酶-1 在脑损伤过程中的作用的研究进展[J].,2011,11(5):961-963 |
| 血红素氧合酶-1 在脑损伤过程中的作用的研究进展 |
| Research progression about role of hemeoxygenase-1 during brain injuries |
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| DOI： |
| 中文关键词: 血红素氧合酶-1 脑损伤 脑保护 |
| 英文关键词: Heme oxygenase-1 brain injuries brain protection |
| 基金项目:兰州军区医药卫生科研基金资助项目(LXH-2007018) |
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| 中文摘要: |
| 来源于出血后血红蛋白或衰老细胞释放的血红素能够诱导血红素氧合酶-1（HO-1,HSP-1）的表达。血红素氧合酶-1 催化血
红素生成气体介质一氧化碳，铁和胆绿素。胆绿素和它的代谢产物胆红素都是有效的抗氧化剂；同时铁诱导的铁蛋白和CO 也发
挥着各自的保护作用。因此，HO-1 的表达被看作一种重要的保护机制。在各种不同的脑病理改变发生后，如蛛网膜下腔出血，脑
梗死，创伤性脑损伤及神经变性疾病，HO-1 明显表达于小胶质细胞，星形细胞和神经元细胞，从而发挥其重要脑保护作用。 |
| 英文摘要: |
| Extracellular heme derived from hemoglobin following hemorrhage or released from dying cells induces the
expression of heme oxygenase-1 (HO-1,HSP-32) which metabolizes heme to the gaseous mediator carbon monoxide(CO),iron(Fe) and
biliverdin. Biliverdin and its product bilirubin are powerful antioxidants..Meanwhile ferritin induced by iron and CO also play
respectively protective effect.Thus, expression of HO-1 is considered to be a protective mechanism.After various kind of brain pathology,
such as subarachnoidal hemorrhage,cerebral infraction,tramatic brain injuries and neurodegenerative diseases,HO-1 expresses obviously
in microglia, astrocyte and neuron,and plays a critical role. |
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