| 乔凌燕陈志红田飞刘栋李堂.23 例1 型糖尿病初发患儿免疫学改变与胰岛β细胞功能的关系[J].,2011,11(5):922-925 |
| 23 例1 型糖尿病初发患儿免疫学改变与胰岛β细胞功能的关系 |
| Relationship between Immunological Change and Function of Islet Beta Cellin 23 Children with Type 1 Diabetes Newly Diagnosed |
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| DOI： |
| 中文关键词: 糖尿病，1 型 淋巴细胞亚群 糖化血红蛋白 胰岛素 C 肽 |
| 英文关键词: Diabetes,type 1 Lymphocyte subsets Glycated hemoglobin Insulin C peptide |
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| 中文摘要: |
| 目的：观察1 型糖尿病（T1DM）初发患儿细胞免疫与胰岛β细胞功能之间的关系。方法：T1DM 组23 例初发患儿均测定淋巴
细胞亚群（T 细胞、B 细胞及NK 细胞）、HbA1c、INS、C-P，正常对照组20 例，测定淋巴细胞亚群。结果：T1DM 组CD4、CD4/CD8 较
正常对照组升高（P<0.05）；CD8、CD3－CD56+ 较对照组降低（P<0.05）；CD4/CD8 比值与HbA1c 呈正相关（r=0.9451，P<0.01），而与
INS 呈负相关(r=-0.1020，P<0.01)，与C-P 呈负相关(r=-0.6174，P<0.01)；CD3－CD56+ 与HbA1c 呈正相关（r=0.1320，P<0.01），而与
INS 呈正相关(r=-0.0846，P<0.01)，与C-P 呈负相关(r=-0.3224，P<0.01)。结论：T1DM 初发患者CD4、CD4/CD8 明显增高，CD8、
CD3－CD56+ 明显降低，提示细胞免疫功能改变与胰岛β细胞功能损伤密切相关。 |
| 英文摘要: |
| Objective: To investigate the relationship between cellular immunity and function of islet beta cell in children with
type 1 diabetes Newly Diagnosed. Methods:Lymphocyte subsets (T cells, B cells, NK cells), HbA1c, INS and C-P were detected in
diabete group (23 children) with type 1 diabetes newly diagnosed. Lymphocyte subsets were measured in normal control group (20
children). Results:The CD4 and the CD4/CD8 ratio in diabetes group was higher than that in normal control group (P<0.05).The
percentage of CD8 and CD3－CD56+decreased compared with that of controls(P<0.05). Both the CD4/CD8 ratio and CD3－CD56+ were
positively correlated with HbA1c. The CD4/CD8 ratio was negatively correlated with INS or C-P. CD3－CD56+ was positively correlated
with INS, but which was negatively correlated with C-P. Conclusions:The percentage of CD4 and the CD4/CD8 ratio in children with
type 1 diabetes Newly Diagnosed incresed significantly, while the percentage of CD8 and CD3 －CD56+ decreased significantly, which
suggested that the change of cellular immunity was closely related with functional damages of islet beta cell. |
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