| 李坤李世平△ 魏发强李俊杰.诱导受体3（DcR3）在胆管癌中的表达及意义[J].,2011,11(5):915-917 |
| 诱导受体3（DcR3）在胆管癌中的表达及意义 |
| The expression and value of DcR3 in cholangiocarcinoma |
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| DOI： |
| 中文关键词: 诱导受体3 胆管癌 ELISA 免疫组织化学 |
| 英文关键词: Decoy receptor 3(DcR3) cholangiocarcinoma Enzyme-linked immunosorbent assay Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：观察胆管癌组织及血清中诱导受体3(decoy receptor 3,DcR3)蛋白的表达及其临床价值。方法：采用免疫组化S-P 法检
测45 例胆管癌、15 例癌旁胆管正常组织中DcR3 蛋白的表达, ELISA 法检测31 例胆管癌及18 例胆道良性疾病患者和28 例正
常人外周血清中DcR3 的水平。结果：45 例胆管癌组织中DcR3 阳性表达29 例,阳性率为64. 4%,胆管正常组织中无阳性表达。
DcR3 的表达与肿瘤临床分期、肿瘤浸润和转移有关(P<0. 05)。胆管癌患者及胆管良性疾病患者血清DcR3 水平分别为152.25
35.94 pg/ml，98.35 14.27 pg/ml，均高于正常人。胆管癌患者与胆道良性疾病患者血清DcR3 水平相比差异有显著性(P<0. 01)。结
论：DcR3 在胆管癌组织中表达增高。DcR3 的表达与胆管癌的发生、发展以及转移有关,可成为治疗胆管癌的一个新靶点。血清
DcR3 的检测对胆管癌的诊断有一定的临床价值。 |
| 英文摘要: |
| Objective: To observe the expression of decoy receptor3(DcR3) in cholangiocarcinoma, and to investigate the value of
serum concentration of DcR3 for the diagnosis of cholangiocarcinoma. Methods: The expression of DcR3 was examined by
immunohistochemistry with SP staining method in 45 cases of cholangiocarcinoma, and 15 cases of bile duct normal tissue. The serum
DcR3 concentration was measured using a DcR3 enzyme-linked immunosorbent assay (ELISA) in 31 cases of cholangiocarcinoma, 18
cases of bile duct benign disease while 28 healthy individuals as contrast. Results: The expression of DcR3 was detected in 29 out of the
45 cholangiocarcinoma cases with a positive rate of 64.4% , no expression of DcR3 was detected in bile duct normal tissue. The
expression of DcR3 was correlated with TNM staging and lymph node metastasis (P<0.05), but not with age, tumor size, histologic
grading (P>0.05). The serum DcR3 concentrations in patients with cholangiocarcinoma and in patients with bile duct benign disease is
152.25 35.94 pg/ml and 98.35 14.27 pg/ml, while the normal people is 95.01 10.03 pg/ml respectively. There was statistical difference in
DcR3 concentration between cholangiocarcinoma patients and bile duct benign disease patients(P<0.01). Conclusions: The expression of
DcR3 increased in cholangiocarcinoma. The expression of DcR3 is closely related to cholangiocarcinoma occurrence, progression and
metastasis. DcR3 can be a new target for the therapy of cholangiocarcinoma. The serum concentration of DcR3 has clinical value for the
diagnosis of Cholangiocarcinoma. |
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