| 郑瑞鹏刘大海王剑峰程光惠姜德福.脑转移瘤局部推量的临床观察[J].,2011,11(5):887-889 |
| 脑转移瘤局部推量的临床观察 |
| Clinical Observation of Amount of Local Push of Radiation Therapy forBrain Metastasis |
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| DOI： |
| 中文关键词: 脑肿瘤/ 放射疗法 转移 放射疗法，局部推量 预后 |
| 英文关键词: Brain tumor/radiotherapy Metastasis Radiotherapy, local plus Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的：观察脑转移瘤放射治疗局部推量的疗效。方法：回顾性分析63 例进行放射治疗脑转移瘤病人，采用6MeV-X 线，两侧
平行相对野作全脑照射，临床靶体积（CTV）包括肿瘤靶体积（GTV）及周围水肿区，处方剂量为30~40Gy，分割次数为10~20 次。
其中27 例缩野后局部推量20Gy。分析常规处方剂量后进行局部推量与未进行局部推量的两个组别局部区域复发率（LRR）、总生
存率（OS）和KPS 评分改变的差别。结果：中位随访6 个月。局部推量组和未局部推量组的LRR 分别为18.5%（5/27）和27.8%
（10/36）；局部推量组和未局部推量组的OS 分别为85.2%（23/27）和77.8%（28/36）；局部推量组和未局部推量组的KPS>=70 分别
为18 和19。结论：脑转移瘤常规处方剂量放疗后进行局部推量对脑转移瘤的局部控制率及KPS 评分有益。 |
| 英文摘要: |
| Objective: To evaluate the efficacy of local plus after Radiotherapy of Brain Metastasis. Methods: From 2007 to
2009,63 patients with Brain Metastasis who were treated with whole brain radiation therapy which CTV included the GTV and tumor's
hydroncus with 6MeV-X rays from two sides in parallel. Of the patients who received radiation therapy with the prescription dose ,
30~40Gy/10~20f,27 received local plus of 20Gy to GTV. End points were isolated locoregional recurrence (LRR), overall survival(OS)
and KPS change. Results: The median follow up time was 6 months. The group with local plus and the other one without local plus' LRR
, OS and KPS>=70 are 18.5%（5/27）and 27.8%（10/36）; 85.2%（23/27）and 77.8%（28/36）；18 and 19 respectively. Conclusions: For
patients with Brain Metastasis, regular radiotherapy combined with local plus can improve the locoregional recurrence and KPS. |
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