| 刘中华陈建英田政湘李丽珍.来氟米特配伍雷公藤多甙治疗难治性肾病综合征的疗效观察[J].,2011,11(4):738-741 |
| 来氟米特配伍雷公藤多甙治疗难治性肾病综合征的疗效观察 |
| Leflunomide Combined with Tripterginum Wilfordii Polyglycoside forRefractory Nephrotic Syndrome |
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| DOI： |
| 中文关键词: 难治性肾病综合征 来氟米特 雷公藤多甙 |
| 英文关键词: Refractory nephrotic syndrome Leflunomide Tripterginum wilfordii polyglycoside |
| 基金项目: |
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| 中文摘要: |
| 目的：观察来氟米特联合雷公藤多甙治疗难治性肾病综合征（RNS）的疗效。方法：选取52例RNS患者随机分为观察组（32
例）与对照组（30例），其中对照组给予来氟米特和激素联合治疗，观察组给予来氟米特配伍雷公藤多甙治疗。疗程均为6 个月，治
疗期间比较两组疗效，检测患者24h 尿蛋白定量、血清总蛋白和白蛋白、血肌酐、血尿素氮、谷丙转氨酶变化情况，同时观察患者
有无不良反应。结果：①治疗6 个月后，观察组完全缓解率和总有效率分别为28.13%、78.13%，略高于对照组26.67%的完全缓解
效率和76..67%的总有效率，但两组间差异无统计学意义（P>0.05)。②经过治疗，RNS患者24h尿蛋白定量逐渐下降，而血清总蛋
白和白蛋白水平逐渐增加，与治疗前比较差异均有显著性(P<0.01)，其中观察组各指标变化比对照组明显（P<0.05) ③治疗后观察
组与对照组患者尿素氮、血肌酐含量均较治疗前显著降低（P<0.01 或0.05)，而谷丙转氨酶水平无明显变化（P>0..05)，两组间差异
无显著性（P>0..05)。④观察组不良反应发生率为12.50%，明显低于对照组23.33%的发生率，组间差异有显著性（P<0.05)。结论：米
氟米特联合雷公藤多甙治疗能明显缓解RNS患者的临床症状，改善肾功能，减少蛋白尿的产生，且短期内不良反应较少。 |
| 英文摘要: |
| Objective: To study the effect of leflunomide (LEF) and tripterginum wilfordii polyglycoside (TWP) in the treatment
of refractory nephrotic syndrome (RNS). Methods: 52 cases of RNS were divided into two groups, the control group (30 cases) was given
LEF and corticosteroids, and the observed group (30 cases) was treated with LEF and TWP. Before and after treatment, the 24h urinary
protein quantitative (Upro), serum total protein (TP), albumin (Alb), serum creatinine (Scr), blood uria nitrogen (BUN), and alanine
aminotransferase (ALT) were observed. Results: ① The complete recession rate and the total efficiency were respectively 28.13% and
78.13% in observed group, slightly higher than that of 26.67% and 76.67% in control group, but there was no significant difference between
groups (P>0.05).②After treatment, the Tb and Alb increased in patients of RNS along with the decrease of Upro, especially in observed
group, showing significant difference between groups (P<0.05). ③With treatment, the Scr and BUN significantly decreased in patients
(P<0.01 or 0.05), while the ALT was changeless, and there was no significant difference between groups (P>0.05). ④The rate of adverse
reactions was 12.50% in observed group, significantly higher than that of control group (23.33%)（P<0.05). Conclusion: The treatment of
refractory nephrotic syndrome with LEF and TWP can obviously relieve the symptom, improve kidney functions, and reduce urine protein,
with less short-term adverse reaction |
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