| 陈波1 邹赛英1△ 陈城2 唐新萍1 马莉1 韩茹1.PKCβⅡ、P53和Ki67在胃印戒细胞癌中的表达
及其与侵袭转移的关系[J].,2011,11(4):711-714 |
| PKCβⅡ、P53和Ki67在胃印戒细胞癌中的表达
及其与侵袭转移的关系 |
| Relation of PKCβⅡ,P53 and Ki67 expression to invasion and metastasisof gastric signet ring cell carcinoma |
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| DOI： |
| 中文关键词: 胃印戒细胞癌 PKCβⅡ P53 Ki67 免疫组织化学 |
| 英文关键词: Gastric signet ring cell carcinoma PKCβⅡ P53 Ki67 Immunohistochemical |
| 基金项目: |
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| 中文摘要: |
| 目的：检测蛋白激酶C-βⅡ亚型（PKCβⅡ），P53，Ki67 三种蛋白在胃印戒细胞癌组织中的表达，探讨三种蛋白与胃印戒细
胞癌侵袭性及转移的关系。方法：应用免疫组化（S-P 法）检测60 例胃印戒细胞癌标本及60 例胃低分化腺癌标本中PKCβⅡ、
p53、Ki67 的表达状况，并将检测结果与浸润深度及淋巴结转移进行综合分析。结果：胃印戒细胞癌和低分化腺癌PKCβⅡ阳性表
达率分别为76.67%和41.67%，二者之间有显著性差异（P＜0.05）；P53阳性表达率分别为43.33%和61.67%，二者之间具有显著性
差异（P＜0.05），Ki67 阳性表达率分别为60.00%和91.67%，二者之间亦具有显著性差异（P＜0.05）。在未侵及浆膜层的印戒细胞
癌和低分化腺癌间P53 的阳性表达率有显著性差异（P＜0.05），而在侵及浆膜及邻近组织的印戒细胞癌和低分化腺癌间PKCβ
Ⅱ和Ki67 的阳性表达率有显著性差异（P＜0.05）；在淋巴结转移的胃印戒细胞癌和低分化腺癌之间PKCβⅡ和Ki67 的阳性表达
率具有显著性差异(P＜0.05）；结论：PKCβⅡ在胃印戒细胞癌高表达，Ki67 在低分化腺癌有较高表达；PKCβⅡ和Ki67 与两种类
型胃癌的晚期浸润及淋巴结转移有关，可能与浸润性侵袭方式相关密切；P53 与两种类型胃癌的早期浸润有关，可能为胃癌发生
的早期事件。 |
| 英文摘要: |
| Objective: T To investigate the expressions of protein kinase C isoforms betaⅡ (PKCβ Ⅱ ),P53 and Ki67 in gastric
signet ring cell carcinoma, and to explore their relationship with the invasion and metastasis of gastric signet ring cell carcinoma.
Methods: Immunohistochemical technique（S-P）was used to detect the expression of PKCβ Ⅱ,P53 and Ki67 in 60 samples ofgastric
signet ring cell carcinoma and poorly differentiated adenocarcinoma , the data were then analyzed in collaboration with the depth of
invasion and lymph node metastasis. Results: The positive expression rate of PKCβⅡin the gastric signet ring cell carcinoma and poorly
differentiated adenocarcinoma was 76.67% and 41.67%, which had significant difference（P＜0.05）. While the positive expression rate of
P53 was 43.33% and 61.67%, which had significant difference （P＜0.05）.And the positive expression rate of Ki67 was 60.00% and
91.67%, which had significant difference（P＜0.05）. The positive expression rate of P53 in the Down-serosa group of the two type of
cancer had significant difference（P＜0.05）. The positive expression rate of PKCβⅡ and Ki67 in the serosa and adjacent organ group of
the two type of cancer had significant difference（P＜0.05）. Conclutions: The expression of PKCβⅡwas higher in the gastric signet ring
cell carcinoma and Ki67 was higher in poorly differentiated adenocarcinoma. PKCβⅡ and Ki67 had correlation with the metastasis of
lymphaden and adjacent organ in the two type of cancer, had related closely with the way of infiltrating invasion；while P53 had
correlation with the earlier period stage of infiltrating in the two type of cancer, probably concerned with earlier event of gastric
carcinoma. |
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