郭晓东杨永平楼敏熊璐曲建慧王春平陆荫英周霖常秀娟
苏淑慧冯永毅.凋亡诱导因子AIF在肝癌组织中的表达及临床意义*[J].,2011,11(3):502-504 |
凋亡诱导因子AIF在肝癌组织中的表达及临床意义* |
Expression of Apoptosis Inducing Factor in Hepatocellular Carcinoma andIts Clinical Signficance |
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DOI: |
中文关键词: 肝细胞癌 凋亡诱导因子 免疫组织化学 |
英文关键词: Hepatocellular carcinoma, Apoptosis inducing factor,Immunohistochemistry |
基金项目:全军十一五基金项目(424134H) |
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中文摘要: |
目的:探讨凋亡诱导因子(AIF)在肝细胞癌组织中的表达及其临床意义。方法:采用免疫组织化学Envision 法检测75例肝细
胞癌组织及其相应癌旁肝组织、30例正常肝组织中AIF的表达,并分析其表达与肝细胞癌临床病理因素的相关性。结果:肝癌组
织中AIF阳性表达率明显高于癌旁组织及正常肝组织,差异均具有统计学意义(P<0.01)。AIF在肝癌组织中的表达仅与病理分级
密切相关(P<0.01),而与年龄、性别、肿瘤大小、临床分期、肿瘤数目、有无肿瘤包膜和有无淋巴结转移、有无门静脉癌栓均无关。结
论:AIF表达可能参与了肝癌的发生和发展过程。 |
英文摘要: |
Objective: To investigate the expression and clinical signficance of AIF in hepatocellular carcinoma tissue. Methods:
The expression of AIF protein was detected with immunohistochemical EnVision plus non-hiotin technique in 75 cases of hepatocellular
carcinoma and pericarcinoma tissues, 30 cases of norma1 tissues. Results: The positive expression rates of AIF protein in hepatocellular
carcinoma were significantly higher than that in pericarcinoma tissues and norma1 tissues (P<0.05). The expression of AIF were positively
related to differentiation degree (P<0.05) |
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