| 黄玲媚罗百灵△ 陈红梅.红霉素对慢性阻塞性肺疾病大鼠ICAM-1、MMP-9的表达影响[J].,2011,11(3):497-501 |
| 红霉素对慢性阻塞性肺疾病大鼠ICAM-1、MMP-9的表达影响 |
| Effect of Erythromycin on Expressions of ICAM-1 and MMP-9in Rats with COPD |
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| DOI： |
| 中文关键词: 红霉素 慢性阻塞性肺疾病 ICAM-1 MMP-9 |
| 英文关键词: Erythromycin Chronic obstructive pulmonary disease ICAM-1 MMP-9 |
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| 中文摘要: |
| 目的：观察慢性阻塞性肺疾病（COPD）大鼠肺组织中ICAM-1及MMP-9的表达及红霉素的干预作用。方法：复制COPD 大
鼠模型，并用红霉素干预，收集支气管肺泡灌洗液行细胞学计数和分类检查；采用HE染色观察病理形态变化；免疫组化法检测大
鼠支气管肺组织ICAM-1、MMP-9 的表达。结果：与模型组比较，干预组支气管肺组织中ICAM-1、MMP-9 表达显著降低；模型组
中ICAM-1、MMP-9 的表达与BALF中白细胞总数及中性粒细胞数成正相关；ICAM-1 与MMP-9 的表达成正相关。结论：COPD
大鼠肺组织中的ICAM-1、MMP-9表达明显升高，可能与COPD 的发病机制有关；红霉素可降低ICAM-1、MMP-9 的表达，可能是
红霉素在COPD中抗炎症反应的作用机制之一。 |
| 英文摘要: |
| Objective: To explore the role of ICAM-1 and MMP-9 in the pathogenesis of COPD, and to study the effects of erythromycin（
EM）on lung ICAM-1 and MMP-9 expression in vivo experiment of COPD rats. Methods: We established COPD rat models
and use Erythromycin to interven. BALF were collected to count the total and differential cell counts. The pathological changes were
observed. The expressions of ICAM-1 and MMP-9 were detected by immunohistochemistry. Results: Compared to the COPD group, the
expression of ICAM-1 and MMP-9 in control group were significantly dcreased; Correlations analyze in COPD group: Both positive correlations
were demonstrated in the expression of ICAM-1 and MMP-9 with WBC counts, PMN counts, PMN counts; Positive correlations
were demonstrated between the expression of ICAM-1 and MMP-9; Conclusions: The difference of expression of ICAM-1 and
MMP-9 between COPD group and control group have statistical significance, which indicate that ICAM-1 and MMP-9 may play important
role in the formation of COPD; EM may play a certain protective role in the treatment of COPD through decreasing the expression of
ICAM-1 and MMP-9 and weakening the inflammatory response. |
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