周莉娜1△ 向江东2.热休克蛋白27 在肿瘤中的研究进展[J].,2011,11(1):198-200 |
热休克蛋白27 在肿瘤中的研究进展 |
Progress of heat shock protein 27 in Tumors |
|
DOI: |
中文关键词: HSP27 肿瘤 耐药 转移 |
英文关键词: Heat shock protein 27 Tumor Drug Resistance Metastasis |
基金项目: |
|
摘要点击次数: 735 |
全文下载次数: 1585 |
中文摘要: |
热休克蛋白27(HSP27)作为热应激蛋白表达于各种生理或是环境损伤之后,保护细胞生存,其具有多种功能包括:分子伴
侣,抗凋亡,参与细胞运动等。近年来发现HSP27 在多种肿瘤中过度表达,参与肿瘤的发生发展,分化,耐药以及转移等方面,因而
抑制HSP27 成为一种新的肿瘤治疗策略。本文就相关研究进展进行综述。 |
英文摘要: |
Heat shock protein 27 (HSP27) is expressed in response to a large amount of physiological and environmental insults,
thus allowing the cell to survive in lethal conditions. HSP27 has complex activities such as molecular chaperones, anti-apoptosis and induce
cell movement. Recently, many researches have found that HSP27 is over-expressed in various tumors, it plays a important role in
tumorigenesis, progress, differentiation, metastasis and chemotherapy resistance. Therefore, the inhibition of HSP27 has become a novel
strategy of cancer therapy. Herein we reviewed the progress of relevant researches. |
查看全文
查看/发表评论 下载PDF阅读器 |
关闭 |
|
|
|