| 周莉娜1△ 向江东2.热休克蛋白27 在肿瘤中的研究进展[J].,2011,11(1):198-200 |
| 热休克蛋白27 在肿瘤中的研究进展 |
| Progress of heat shock protein 27 in Tumors |
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| DOI： |
| 中文关键词: HSP27 肿瘤 耐药 转移 |
| 英文关键词: Heat shock protein 27 Tumor Drug Resistance Metastasis |
| 基金项目: |
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| 摘要点击次数: 643 |
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| 中文摘要: |
| 热休克蛋白27(HSP27)作为热应激蛋白表达于各种生理或是环境损伤之后，保护细胞生存，其具有多种功能包括：分子伴
侣，抗凋亡，参与细胞运动等。近年来发现HSP27 在多种肿瘤中过度表达，参与肿瘤的发生发展，分化，耐药以及转移等方面，因而
抑制HSP27 成为一种新的肿瘤治疗策略。本文就相关研究进展进行综述。 |
| 英文摘要: |
| Heat shock protein 27 (HSP27) is expressed in response to a large amount of physiological and environmental insults,
thus allowing the cell to survive in lethal conditions. HSP27 has complex activities such as molecular chaperones, anti-apoptosis and induce
cell movement. Recently, many researches have found that HSP27 is over-expressed in various tumors, it plays a important role in
tumorigenesis, progress, differentiation, metastasis and chemotherapy resistance. Therefore, the inhibition of HSP27 has become a novel
strategy of cancer therapy. Herein we reviewed the progress of relevant researches. |
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