| 秦斌齐静△.肌肉31P-MRS 的临床研究进展[J].,2011,11(1):176-179 |
| 肌肉31P-MRS 的临床研究进展 |
| Clinical Research of 31P-MRS for Skeletal Muscle |
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| DOI： |
| 中文关键词: 磁共振磷谱（31P-MRS） 骨骼肌 氧化磷酸化 能量代谢 |
| 英文关键词: phosphorus-31 magnetic resonance spectroscopy (31P-MRS) skeletal muscle Oxidative phosphorylation energy
metabolism |
| 基金项目:国家自然科学基金资助项目（30700191）；江苏省自然科学基金资助项目(BK2006578) |
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| 中文摘要: |
| 磁共振波谱分析(magnetic resonance spectroscopy MRS)是目前唯一无创性定量研究人体组织细胞代谢、生理生化改变的方
法。磁共振磷谱(31P-MRS)可对无机磷(Pi)、磷酸肌酸(PCr)、三磷酸腺苷(ATP)等含磷高能化合物进行定量分析，是在体研究骨骼肌
能量代谢的有力工具。动态磷谱技术可测量肌肉在静息状态、收缩过程和恢复过程中细胞内高能磷酸化合物的变化，评价骨骼肌
做功时的能量的转换效率，实现对线粒体功能的无创性评价。本文将对肌肉磷谱的研究进展做综述，尤其侧重于动态磷谱的应
用，为以后利用磷谱客观研究肌肉相关疾病奠定良好的基础。 |
| 英文摘要: |
| As one type of Magnetic Resonance Spectroscopy (MRS), Phosphorus MR spectroscopy(31P-MRS) has special effect
in the analysis of energy metabolism of human tissue and cell in vivo, it can quantitatively analyse of the concentrations of inorganic
phosphate(Pi), phosphocreatine(PCr), adenosine triphosphate(ATP) and so on. so it plays an important role in the study of skeletal muscle
and energy metabolism. Dynamic 31P-MRS technique can survey the change of high energy phosphate compounds in muscle cells during
resting state, during and after exercise, evaluate energy conversion efficiency during mucle contraction. This paper reviewed the research
of mucle 31P-MRS, particularly focused on the application of the dynamic 31P-MRS. It will lay a good foundation for using the 31P-MRS
to study the diseases related to muscles. |
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