| 丁立新 刘 莉 明旭昌 刘瑶娟.高频电磁场曝露对胃粘膜急性损伤的
治疗效应及作用机制研究[J].,2006,6(8):22-23 |
| 高频电磁场曝露对胃粘膜急性损伤的
治疗效应及作用机制研究 |
| Study on Therapeutic Effect and Mechanism of High-frequency ElectromagneticFields on Acute Gastric Mucosal Injuries in Rats |
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| DOI： |
| 中文关键词: 高频电磁场 大鼠 胃粘膜损伤 内皮素 一氧化氮 超氧化物岐化酶 |
| 英文关键词: High-frequency electromagnetic field Rat Acute gastric mucosal injury Endothelin Nitric oxide Superoxide dismutase |
| 基金项目: |
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| 中文摘要: |
| 目的:探讨高频电磁场曝露对大鼠胃粘膜急性损伤的治疗效应, 以及血管内皮素1(endothelin-1 , ET-1)、一氧化氮
(nitric oxide , NO)及超氧化物岐化酶(superoxide dismutase , SOD)在高频电磁场这一效应中的作用。方法:SD 大鼠胃粘膜急性损伤
模型采用indomethacin 灌胃法复制, 高频电磁场曝露的条件为频率40.68MHz, 电流输出30-50mA, 曝露15min, 1/d , 对照组电磁场
曝露条件相同, 但无电流输出, 观察电磁场曝露1 或6 次后大鼠胃粘膜损伤程度以及血浆ET-1、NO 和SOD 水平的变化。结果:
电磁场曝露1 次后, 急性胃损伤大鼠胃粘膜损伤程度较对照组并无显著性差异(p>0.05), 血ET -1 和NO 水平均明显增高(p 均
<0 .05);曝露6 次后, 胃粘膜损伤程度较对照组明显改善(p<0.05), 但血ET-1 和NO 水平则与对照组无显著性差异(p >0 .05),
血SOD 水平在电磁场曝露1 或6 次后均无显著意义的变化(p 均>0 .05)。结论:40.68MHz 高频电磁场30 -50mA 曝露对大鼠胃
粘膜急性损伤, 呈现出有效的治疗效应, 高频电磁场这一作用机制与ET-1、NO 及SOD 无关。 |
| 英文摘要: |
| Objective :To study the therapeutic effect of the exposure of high-frequency electromagnetic fields(HEMF)on acute gastric
mucosal injuries in rats, and to elucidate whether endothelin-1(ET-1), nitric oxide(NO)and superoxide dismutase(SOD)are involved in the
therapeutic mechanism of HEMF.Methods :Immediately after the models of acute gastric mucosal injury in rats were made by gastricgavage of indomethacin
, rats in experiment groups were exposed to 40 .68MHz, 7 .3m HEMF (30 -50mA)for 15 minutes, 1/ d, while rats in control group
were sham -exposed to HEMF with no electric current output.After exposure to HEMF once or six times, the degree of gastric injury(injury index
and integral of pathological diagnosis), and the levels of ET -1, NO and SOD in plasma were measured.Results:Compared to control
group, after exposure to HEMF once , there was no significant change in the degree of gastric injury for the rats in experiment group (p both >0 .
05), while the levels of plasma ET-1 and NO increased markedly (p both<0 .05);following exposure to HEMF for six times , the degree of
gastric injury was improved in experiment group(p both <0.05), with no marked difference in the levels of ET-1 and NO between experiment
and control groups(p both >0 .05);there was no significant change in the level of plasma SOD after exposure either once or for six times(p both
>0 .05).Conclusion:Exposure to 30-50mA, 40 .68MHz HEMF 15 min for six times is an effective prescription for acute gastric mucosal injury
in rats , and ET-1, NO and SOD are not involved in the therapeutic mechanism of HEMF. |
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