| 丁立新 刘 莉 明旭昌 刘瑶娟.表皮生长因子和降钙素基因相关肽在高频电磁场
治疗急性胃损伤中作用研究[J].,2006,6(7):22-23 |
| 表皮生长因子和降钙素基因相关肽在高频电磁场
治疗急性胃损伤中作用研究 |
| Study of Role of EGF and CGRP in Exposure of HEMFs in TreatingAcute Gastric Mucosal Injuries in Rats |
| |
| DOI： |
| 中文关键词: 高频电磁场 大鼠 胃粘膜急性损伤 胃粘膜血流量 表皮生长因子 降钙素基因相关肽 |
| 英文关键词: High- frequency electromagnetic fields Rat Acute gastric mucosal injury Gastric mucosal blood flow Epidermal growth
factor Calcitonin gene- related peptide |
| 基金项目: |
|
| 摘要点击次数: 1104 |
| 全文下载次数: 863 |
| 中文摘要: |
| 目的: 探讨高频电磁场( high- frequency electromagnetic fields, HEMFs) 曝露治疗急性胃损伤的作用机制。方法: 选用健
康SD 大鼠, 以Indomethacin 灌胃法复制胃粘膜急性损伤模型, 观察40. 68MHz HEMFs( 波长为7. 3m) 曝露( 微热量, 30- 50mA,
15min, 1/ d) 治疗1 或6 次后, 大鼠胃粘膜损伤程度( 胃损伤指数和病理损伤积分) 、胃粘膜血流量、血浆表皮生长因子( epidermal
growth factor, EGF) 和降钙素基因相关肽( calcitonin gene- related peptide, CGRP) 水平。结果: HEMFs 曝露1 次后, 胃粘膜血流量较
对照组明显升高( p< 0. 05) , 大鼠胃粘膜损伤程度、血浆EGF 和CGRP 水平较对照组均无显著性差异( p 均> 0. 05) ; HEMFs 曝露6
次后, 胃粘膜损伤程度较对照组明显改善( p 均< 0. 05) , 胃粘膜血流量显著升高( p< 0. 05) , 血浆EGF 和CGRP 水平较对照组无显
著性差异( p 均> 0. 05) 。结论: HEMFs 曝露治疗大鼠胃粘膜急性损伤可能与其增加胃粘膜血流量有关, 与血EGF 和CGRP 无关。 |
| 英文摘要: |
| Objective: To elucidate the treatment mechanism of the exposure of high- frequency electromagnetic fields( HEMFs) to
acute gastric mucosal injuries in rats. Methods: The models of acute gastric mucosal injuries were replaced with the gastricgavage of indomethacin
in healthy SD rats. The rats in experiment groups were exposed to 40. 68MHz HEMFs( 30- 50mA) for 15 minutes, 1/ d, while rats in
control groups were exposed to HEMFs without electric current output. After exposed toHEMFs once or for six times, the degree of gastricmucosal
injury( injury index and integral of pathological diagnosis) , gastric mucosal blood flow( GMBF) , and the levels of epidermal growth factor( EGF)
and calcitonin gene- related peptide( CGRP) in plasma were observed. Results: After exposed to HEMFs once, the level of the rats. GMBF in
experiment group was much higher than that in control group( p< 0. 05) , the degree of gastric mucosal injuries( DGMI) and the levels of EGF and
CGRP in plasma in experiment group showed no significant difference from those in control group( p all> 0. 05) . After exposed to HEMFs for six
times, the degree of gastric mucosal injuries was significantly reduced( p all< 0. 05) , and GMBF increased( p< 0. 05) , but there was no marked
difference in the levels of EGF and CGRP between experiment and control groups( p all> 0. 05) . Conclusion: The therapeutic mechanism of
HEMFs on acute gastric mucosal injuries in rats is related to the increase of GMBF, not to EGF and CGRP in plasma. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
