| 程孟荣1 沈 俊2 李 擎1 金波1 楼利高1 黄青阳1.胰岛素受体基因多态性与2 型糖尿病的相关性[J].,2006,6(3):5-7 |
| 胰岛素受体基因多态性与2 型糖尿病的相关性 |
| Study on correlation between INSR gene polymorphismand type 2 diabetes mellitus |
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| DOI： |
| 中文关键词: 胰岛素受体 基因多态性 2 型糖尿病 相关性 |
| 英文关键词: Insulin receptor( INSR) gene Type 2 diabetes mellitus Polymorphism Correlation |
| 基金项目:国家自然科学基金资助项目( No. 30340068) , 湖北省自然科学基金资助项目 |
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| 中文摘要: |
| 目的: 探讨胰岛素受体基因( INSR) 的第8 外显子Nsi? 多态性与湖北汉族人群2 型糖尿病的相关性; 方法: 采用同胞
对( 家系内对照) 和随机病例- 对照两种实验设计, 并结合聚合酶链反应- 限制性片断长度多态性( PCR- RFLP) 技术分析了224
个样本的INSR 基因第8 外显子Nsi? 多态性, 并测定了身高、体重、腰围、臀围、血压和空腹血糖等生理指标; 结果: 两种实验设计
中对照组与病例组的基因型和基因频率均无显著差异; 结论: INSR 基因在湖北汉族人群2 型糖尿病的发生发展中可能不起主要
作用。 |
| 英文摘要: |
| Objective: To investigate the correlation between insulin receptor ( INSR) gene Nsi ? polymorphism of exon 8 and type 2
diabetes mellitus in Hubei Han people. Methods: Both sib- pairs and random case- control designs were used. The genotypes in 224 samples
were examined using polymerase chain reaction- restriction fragment length polymorphism ( PCR- RFLP) . Height, weight, blood pressure and
fasting blood glucose were measured. Results: In two experimental designs, there were no significant differences in the genotype and gene frequency
between cases and controls. Conclusion: Type 2 diabetes mellitus may be little associated with INSR gene Nsi? polymorphism of exon
8 in Hubei Han people. |
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