| 吴云霞 黄光英.补肾益气活血汤对小鼠血清雌、孕激素浓度
及其受体表达的影响[J].,2006,6(2):19-21 |
| 补肾益气活血汤对小鼠血清雌、孕激素浓度
及其受体表达的影响 |
| Clinical Significance of High Frequency Ultrasound in Detection of Thyroid Nodule Calcification |
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| DOI： |
| 中文关键词: 补肾益气活血汤 雌激素 孕激素 |
| 英文关键词: Thyroid Nodules Calcification High Frequency Ultrasound |
| 基金项目:国家高等学校博士学科点专项科研基金资助( NO: 20020487058) |
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| 中文摘要: |
| 目的: 探讨中药补肾益气活血汤促进着床的机理。方法: 在以吲哚美辛建立小鼠着床障碍模型的基础上, 将动物分为
正常组, 吲哚美辛组, 中药组和黄体酮组, 用放射免疫、免疫组织化学及Western- blot 方法检测各组小鼠妊娠d5( 围着床期) 血清
E2, P4 浓度及子宫内膜ER, PR 表达。结果: 补肾益气活血中药对E2、P4 水平无明显影响, 对PR 表达也无明显影响, 但有轻度促
进ERA表达作用, 此外, 实验发现治疗对照组注射黄体酮虽然使P4 水平升高, 但ERA、PR 表达却都有一定下降。结论: 提示中药
补肾益气活血汤可能主要通过雌激素样活性加强E2 与其受体作用而有利于发动蜕膜化从而促进着床, 黄体酮辅助生殖治疗失
败可能与孕酮一定程度上抑制ERA和PR 表达有关。 |
| 英文摘要: |
| Objective: To investigate the clinical significance of thyroid calcification in the differential diagnosis of thyroid carcinoma.
Methods: The clinical data of 77 patients( male: 20, female: 57) with thyroid nodules, who were confirmed by preoperative ultrasonic examination
and postoperative pathological results, were retrospectively analysed. Results: Among the patients, there were 20 with benign nodules, 56 with
malignant tumor, and 1 with precancerous lesion. In this study, calcification rates in benign and malignant diseases were 10% and 14. 28% respectively,
with significant difference. Conclusion: According to the size of thyroid nodule calcification, whether malignant disease or not can be
diagnosed, so if micro- calcification in thyroid nodules is detected by preoperative ultrasound, malignant tumor of thyroid should be highly doubted
and paid more attention to, especially for the young or patients with single nodule. |
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